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EDUCATIONAL INFORMATION

BIOAVAILABILITY MATTERS

Taking CBD sublingually (under the tongue) allows for quicker and more efficient absorption compared to digesting it through the stomach. Here are the key reasons:

Faster Absorption: Sublingual administration bypasses the digestive system and liver metabolism, allowing CBD to enter the bloodstream directly through the mucous membranes under the tongue. This leads to faster onset of effects, typically within 2 to 3 minutes.


Higher Bioavailability: When CBD is ingested orally and passes through the digestive system, it undergoes the first-pass metabolism in the liver, which can significantly reduce the amount of active CBD that reaches the bloodstream. Sublingual administration avoids this, resulting in higher bioavailability, meaning more CBD is available for use by the body.


Consistency of Effects: The digestive process can be influenced by factors such as food intake, digestive enzymes, and stomach acids, which can affect the consistency and predictability of CBD’s effects. Sublingual administration provides more consistent and reliable effects since it bypasses these variables.
Convenience and Discretion: Sublingual CBD products, such as tinctures, are often more convenient and discreet to use compared to edibles or capsules.


Overall, sublingual administration of CBD is often preferred for its quicker onset, higher bioavailability, and more predictable effects.

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CBD TINCTURES

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CBD tinctures, particularly those containing pure CBD, have been studied for their potential benefits in treating epilepsy. The most notable and approved benefit is the treatment of certain types of epilepsy. Here are the key points:

FDA Approval: The FDA has approved a CBD-based medication called Epidiolex for the treatment of seizures associated with two rare and severe forms of epilepsy, Lennox-Gastaut syndrome and Dravet syndrome, as well as for seizures associated with tuberous sclerosis complex (TSC).


Reduction in Seizure Frequency: Clinical trials have shown that Epidiolex can significantly reduce the frequency of seizures in patients with these conditions. This has provided substantial relief for patients who often do not respond well to conventional anti-seizure medications.


Safety and Efficacy: The approval of Epidiolex was based on robust clinical trials that demonstrated both its safety and efficacy. While side effects can occur, they are generally considered manageable compared to the potential benefits for individuals with severe, treatment-resistant epilepsy.


Quality of Life: Beyond seizure reduction, some patients report improvements in overall quality of life, including better sleep, mood, and cognitive function, although these benefits are more anecdotal and require further study.


It's important to note that while Epidiolex is an approved treatment, other CBD products, like the ones we offer here at NC Hemp Zone including over-the-counter tinctures, are not regulated in the same way.  However, we at NC Hemp Zone only use the highest quality tinctures to cover a myriad of ailments, but others may vary in quality and potency. Patients considering CBD for epilepsy should do so under the guidance of a healthcare professional.

MAIN BENEFITS OF CBD

CBD (cannabidiol) is a non-psychoactive compound found in cannabis plants, and it has been studied for its potential therapeutic benefits. Here are some of the main benefits of CBD:

Pain Relief: CBD is known for its analgesic properties and is used to manage various types of pain, including chronic pain, neuropathic pain, and pain associated with conditions like arthritis and multiple sclerosis.


Anti-Inflammatory Effects: CBD has anti-inflammatory properties that can help reduce inflammation, which is beneficial for conditions like arthritis, inflammatory bowel disease, and other inflammatory disorders.


Anxiety and Stress Reduction: CBD has been shown to have anxiolytic effects, which can help reduce anxiety and stress. It is often used for conditions like generalized anxiety disorder, social anxiety disorder, and post-traumatic stress disorder (PTSD).


Improved Sleep: CBD can help improve sleep quality and is used by people with insomnia or other sleep disorders. It may help regulate sleep patterns and reduce the impact of factors that disrupt sleep, such as anxiety and pain.


Epilepsy and Seizure Control: One of the most well-documented benefits of CBD is its ability to reduce the frequency and severity of seizures in certain types of epilepsy, particularly Lennox-Gastaut syndrome and Dravet syndrome. The FDA-approved drug Epidiolex is a CBD-based treatment for these conditions.


Neuroprotective Properties: CBD has neuroprotective effects, which may be beneficial for neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and multiple sclerosis. It may help protect neurons from damage and reduce neuroinflammation.
Mental Health and Mood Disorders: CBD is being studied for its potential to help with various mental health and mood disorders, including depression, bipolar disorder, and schizophrenia. Its effects on serotonin receptors in the brain are thought to contribute to its mood-regulating properties.


Substance Abuse Treatment: CBD may help reduce cravings and withdrawal symptoms in people with substance use disorders, including opioid, tobacco, and alcohol addiction. It is being researched as a potential aid in addiction recovery.


Skin Health: Topical CBD products are used for various skin conditions, including acne, eczema, and psoriasis. CBD's anti-inflammatory and sebostatic properties can help reduce skin inflammation and oil production.


Cardiovascular Health: Some studies suggest that CBD may have benefits for cardiovascular health, including reducing blood pressure, improving blood flow, and reducing oxidative stress and inflammation in the cardiovascular system.


While these benefits are promising, it's important to note that more research is needed to fully understand the efficacy and safety of CBD for many of these uses. Individuals should consult with a healthcare provider before starting CBD, especially if they are taking other medications or have underlying health conditions.

Pre-Rolls

CBD (cannabidiol) has gained popularity for its potential to alleviate various types of pain. While research is ongoing, there are some indications that CBD may be effective for certain pain conditions. Here’s an overview of the current understanding of CBD for pain relief:

Chronic Pain: Some studies suggest that CBD may help reduce chronic pain by interacting with the endocannabinoid system (ECS), which regulates various physiological processes including pain perception. CBD is believed to influence ECS receptors to modulate pain and inflammation.


Neuropathic Pain: CBD may be particularly beneficial for neuropathic pain, which results from nerve damage. Research indicates that CBD may help reduce pain and improve sleep quality in patients with conditions like multiple sclerosis and peripheral neuropathy.
Arthritis: Preclinical studies have shown that CBD can reduce inflammation and pain in animal models of arthritis. While more human studies are needed, some people with arthritis report relief from pain and improved joint function when using CBD.


Cancer-related Pain: CBD has been studied for its potential to alleviate pain associated with cancer and its treatment. Some research indicates that CBD, especially when combined with THC, may help reduce pain and improve quality of life for cancer patients.
Fibromyalgia: There is some evidence to suggest that CBD might help reduce pain and improve sleep in individuals with fibromyalgia, although research is still limited and more studies are needed.


Migraines: While research is still in early stages, some studies and anecdotal evidence suggest that CBD might help reduce the frequency and severity of migraine attacks.


Mechanisms of Action
CBD is believed to relieve pain through various mechanisms:

Anti-inflammatory Properties: CBD may reduce inflammation, which is a common cause of pain.


Interaction with Neurotransmitters: CBD may impact neurotransmitters involved in pain regulation, such as serotonin and anandamide.


Modulation of Pain Signals: CBD may alter the way pain signals are transmitted in the brain and spinal cord.


Safety and Side Effects
CBD is generally considered safe, with a favorable side effect profile. Common side effects may include dry mouth, dizziness, and changes in appetite. It's important for individuals to consult with a healthcare provider before starting CBD, especially if they are taking other medications or have underlying health conditions.

Conclusion
While CBD shows promise for pain relief, more high-quality clinical trials are needed to fully understand its efficacy and safety. It’s also important to use high-quality, lab-tested CBD products to ensure proper dosage and avoid contaminants.

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